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Fioricet is a combination drug. This means it is made up of three separate drugs: Butalbital, Acetaminophen, and Caffeine. It is used to treat tension headaches and to reduce a fever. Butalbital is a barbiturate that relaxes muscles. Acetaminophen relieves pain and reduces fever, while caffeine dilates blood vessels and improves the flow of blood. The combined effect is to allow tense muscles to relax and help the headache go away. Under no circumstances should you take fioricet with one of the MAO inhibitor antidepressants. The results can be dangerous. Always get a doctor’s advice before mixing different drugs.